Ozempic for weight loss: Does it work, and what do experts recommend?

Approximately 42% of American adults are obese, as reported by the Centers for Disease Control and Prevention (CDC). Over the years, individuals have explored various methods and medications in pursuit of the ultimate weight loss solution.

A recent trend that has captured significant attention is the utilization of the diabetes drug Ozempic for weight loss.

What does the research say about using this drug? Are health professionals recommending Ozempic for weight loss goals? Our experts address these questions and more.

## What is Ozempic?

Ozempic, also known as semaglutide, received approval from the U.S. Food and Drug Administration (FDA) in 2017 for treating adults with type 2 diabetes.

Ozempic is a weekly injection that aids in reducing blood sugar levels by enhancing insulin production in the pancreas. While not originally sanctioned for weight loss, some doctors prescribe it for this purpose.

## How does Ozempic work?

Ozempic operates by mimicking a naturally occurring hormone. As the levels of this hormone increase, signals are sent to the brain indicating satiety. Additionally, it slows down digestion, prolonging the time food remains in the body, akin to the effects of bariatric surgery.

Weight loss is a common side effect of Ozempic when used to manage diabetes, and it is intended for long-term use.

## Does Ozempic effectively aid in weight loss?

Research supports the efficacy of the active ingredient in Ozempic, semaglutide, for weight loss. It is crucial for individuals to maintain lifestyle modifications, such as proper nutrition and exercise, to enhance their weight loss journey.

While Ozempic is not endorsed for weight loss, semaglutide is approved for weight management under the name Wegovy, albeit in higher doses than found in Ozempic.

It is noteworthy that starting either of these medications for weight loss may lead to your body adapting, potentially causing weight plateaus. Studies suggest that discontinuing Ozempic (or Wegovy) might result in regaining lost weight.

## What sets Ozempic apart from Wegovy?

Wegovy, an FDA-approved once-weekly injection for chronic weight management since 2021, is the first drug authorized for this purpose since 2014.

Both Ozempic and Wegovy are products of the same manufacturer and contain semaglutide as the active ingredient. However, Wegovy features higher semaglutide doses tailored for weight loss, whereas Ozempic, with lower semaglutide doses, was primarily developed for type 2 diabetes patients.

Another distinction is that Ozempic is typically covered by health insurance, whereas Wegovy often lacks coverage.

## Are there advantages to using Ozempic for weight loss?

Ozempic can facilitate weight loss, reducing the risk of various serious health conditions like cardiovascular issues. Semaglutide treatments can serve as an alternative to bariatric surgery for certain obese patients. Nevertheless, surgical weight loss often yields more substantial and enduring results compared to medication-based approaches.

Experts advise against Ozempic use unless for type 2 diabetes management. Instead, consult your healthcare provider about commencing Wegovy for weight loss.

## Is there a generic version of Ozempic available?

The FDA cautions against using "generic" Ozempic and Wegovy, emphasizing the absence of approved generic versions of these drugs.

Despite this, an unbranded version of the medication has surfaced at compounding pharmacies nationwide. Reports of adverse effects following the usage of "generic" semaglutide, the key component in Ozempic and Wegovy, have reached the FDA.

A drug shortage involving Ozempic and Wegovy has been reported as of July 2023. Misuse of Ozempic for weight loss may impede type 2 diabetes patients reliant on the medication from accessing it.